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Monthly Archives: August 2018

Haplotypes vs. genetic mutations

With August proofs, we saw a new and unique situation with two Alta sires: newly released sexed-only 11HO12240 AltaMILESTONE and G-STAR sire, 11HO11740 AltaFACET.

AltaMILESTONE’s initial genomic test told us he was free from the HH5 haplotype. However, the more extensive gene test for the causative mutation told us he is, in fact, an HH5-carrier. Similarly, AltaFACET was initially coded as free from the HH3 haplotype, but a later gene test revealed he is an HH3-carrier.

Traditionally, haplotypes are identified when animals have the same extended sequence of about 100 SNPs. Because we know there is more to this than the currently identified haplotypes, researchers are working to identify the exact causative mutations that cause early embryonic death1,2. This causative mutation is located in between two of the 100 SNPs used in the haplotype identification, but prior to finding the true causative mutation the exact location was unknown.

Over time, crossover events that occur in the DNA during sperm and egg creation can breakup and reassemble parts of an animal’s genome. That’s why we often see so much diversity in the progeny from a single mating pair.

These crossover events can also breakup that sequence of the 100 SNPs that we traditionally use to identify the haplotypes. If this happens, an animal could still have the causative mutation, but only have 40 of the 100 SNPs that would identify them as a haplotype carrier.

As researchers continue to identify the causative mutations for negative haplotypes, the specific gene tests will eventually replace the current haplotype tests used by the CDCB.

Although crossover events frequently happen in gamete formation, this process rarely occurs within the lethal haplotypes. In fact, these are the first instances of inconsistent haplotype results for Alta marketed sires.

For full disclosure, it’s important to remember that AltaMILESTONE (HH5) and AltaFACET (HH3) both have the causative mutation for their respective haplotypes and will therefore be labeled as carriers on Alta’s proof materials and website.

 

1Shutz et al. 2016. The Holstein Friesian Lethal Haplotype 5 (HH5) Results from a Complete Deletion of TBF1M and Cholesterol Deficiency (CDH) from an ERV-(LTR) Insertion into the Coding Region of APOB. PLoS ONE 11:e0154602.

2McClure et al. 2014. Bovine Exome Sequence Analysis and Targeted SNP Genotyping of Recessive Fertility Defects BH1, HH2, and HH3 Reveal a Putative Causative Mutation in SMC2 for HH3. PLoS One 9(3):e92769.

 

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What you need to know about August proofs

1. You’ve got a lot of high-ranking, brand-new sire options!

Never before have you had access to more new sires atop the Alta ADVANTAGE, G-STAR, daughter-proven, and Alta511 sexed sire lists! These sires are diverse in what they offer, and they are readily available!

2. You can now take a precision approach to herd fertility management

Starting this proof round, we give you options to most accurately and efficiently manage your herd’s fertility. (Read more about it HERE).

You can now select the right genetics for your herd based on your breeding strategy. We’ve released a sire fertility rating for conventional semen, and a separate sire fertility evaluation based on breedings with sexed semen.

These separate, and lowly correlated ratings will help you create more pregnancies by using the right sire fertility evaluation for your strategy and situation.

Full-size version of the new 511 CONCEPT PLUS logo

Know which bulls will give you highest fertility using Alta511 SexedULTRA semen by finding this 511 CONCEPT PLUS designation on a bull’s individual page on Alta Bull Search.

The industry’s most accurate sire fertility evaluation, CONCEPT PLUS designates whether a bull offers elite fertility on conventional breedings.

3. Some proof numbers were adjusted

  • NM$the index has new weights, and the average change across the industry meant a general increase of about 10 NM$. But many individual bulls changed more than that!
  • DPR – to account for the entire industry DPR drop that happened in April, the average DPR went up this proof round in the following amounts:
    • Holsteins: approximately +1.4 DPR increase
    • Jerseys: approximately +0.5 DPR increase
  • TPI – the average bull increased about 25 TPI points. However, several bulls atop our daughter-proven lineup increased 100 points or more!

4. The most efficient way to reach your genetic and reproductive goals is to set and follow your own, customized genetic plan.

Work with your trusted Alta advisor to set your strategy, and see how you can implement the exciting, new sire options and approach to precision fertility management in your herd.

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Newest Daughter-proven options to fit your genetic plan

Side-by-side professional photos of daughters by AltaLEAF and AltaSPRING

Is high reliability part of your genetic plan? If so, select from several sire options atop our daughter-proven lineup. These bulls are either new to the proven ranks, or have just added new daughter information.

011HO11478 AltaLEAF and 011HO11437 AltaSPRING are international producer favorites that remain atop our daughter-proven ranks. With the addition of hundreds of daughters each, both of these household names gained significant TPI points and Net Merit $!

These new bulls to the daughter-proven lineup offer a wide range of trait specialties to fit many different customized g­enetic plans.

11HO11531 AltaSABRE | JACEY X ROBUST X PLANET | 511 | 2624 TPI

  • Health trait outlier at 4.2 DPR and 7.7 PL
  • Tall, strong cows with high, wide rear udder attachments and ideal feet and legs
Grazing photo of Cottonwood Sabre 1535
Cottonwood Sabre 1535 | Cottonwood Dairy | South Wayne, WI

11HO11493 AltaHOTROD | JEROD X AltaIOTA X GOLDWYN | 511 | 2616 TPI

  • Great production, high type, and solid daughter fertility
  • Tall, long, stylish cows
  • Youthful, well-attached udders – protect for short teats
Professional side shot daughter photo of Parbro HOTROD Hannah, daughter of 11HO11493 AltaHOTROD
Parbro HOTROD Hannah | Owner: Parbro Farms | Uxbridge, ON

11HO11601 AltaHIFASHN | MAYFLOWER X MASSEY X OMAN | 2588 TPI

  • Great commercial cows with excellent rear udders
  • A balanced proof with sound production numbers, great health and fertility, and great functional type!

11HO11523 AltaHOTSHOT | PRIDE X CAMERON X MAN-O-MAN | 2576 TPI

  • Medium framed cows with strong fore udder attachments
  • By adding daughters, he improved 100 TPI points and 108 NM$
  • Outcross sire

11HO11499 AltaMEGLO | SUPERSIRE X FREDDIE X PLANET | 511 | 2572 TPI

  • Small to medium sized cows with open rib and strong udder attachments
  • Unique combination of excellent production (1962 Milk, 135 CFP) with exceptional 3.6 DPR
  • Outlier for conventional sire fertility

11HO11508 AltaCONSUL | AltaEMBASSY X ROBUST X PLANET | 2547 TPI

  • Wide rumps, high clearance udders and longer teat length
  • Great combination of high production and favorable health traits

11HO11537 AltaJANGO | TANGO X SHAMROCK X FREDDIE | 2508 TPI

  • Health and type trait specialist
  • DPR of 2.7 and SCS at 2.78
  • Favorable type traits at 2.13 UDC, 1.98 FLC
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August sire lists

No matter what genetic plan you’ve put in place on your farm, we have daughter-proven and genomic-proven bulls to meet your goals.

We have access to all you need in one place, in formats that are easy to print. Here you will find lists to download with any of Alta’s Holstein and Jersey specialty sires. Below, are the A2A2, polled, outcross, robot-suited and kappa casein sires. There is also a listing of our milking speed ratings, 100% registry status listings and top wellness trait sires.

Work with your trusted Alta advisor to customize your genetic plan using our Advanced Bull Search or Alta GPS.

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Create more pregnancies with precision fertility management

Big data is sweeping into agribusiness with precision agriculture. Now, with more information, growing crops and livestock has become more accurate and efficient, allowing you to do more for less.

We’re taking precision agriculture one step further. With precision fertility management, we are helping you turn data into dollars by creating more pregnancies.

Backed by the CONCEPT PLUS gold standard fertility designation, we’ve raised 20 years of fertility experience to a higher standard. We’ve compiled millions of pregnancy check data and delivered it through innovate tools to accurately and efficiently create pregnant cows.

Bullseye icon to stand for precision fertility management

What’s new with CONCEPT PLUS?

If you’ve used sexed semen on your dairy, you already know what millions of pregnancy check results confirm. Sexed semen fertility is not the same as conventional semen fertility.

The data also shows that the same bull may perform well with conventional semen fertility, but not as sexed semen, and vice versa. With that in mind, we now give you access to two separate fertility evaluations, so you can take a precision approach to fertility management.

Full-size version of the new 511 CONCEPT PLUS logo

Know which bulls will give you highest fertility using Alta511 SexedULTRA semen by finding this 511 CONCEPT PLUS designation on a bull’s individual page on Alta Bull Search.

The industry’s most accurate sire fertility evaluation, CONCEPT PLUS designates whether a bull offers elite fertility on conventional breedings.

Can a bull be CONCEPT PLUS and 511 CONCEPT PLUS?

Yes. Since we know that conventional semen fertility and sexed semen fertility are two different traits with low correlations, we now identify them as such. An orange CONCEPT PLUS icon or logo designates the bulls with the best fertility on conventional semen. The purple 511 CONCEPT PLUS logo shows you which sires offer the best fertility on breedings to Alta511 SexedULTRA.

Why would I want to use sexed semen with average or unknown fertility?

As with any decision you make, there are trade-offs. With Alta’s sexed semen options, it comes down to what you value most in a genetic plan: the most rapid genetic progress or known high fertility.

Let’s say the main goal in your genetic plan is to make the fastest genetic progress possible. In that case you may choose to use bulls that don’t yet have fertility data, or else are proven as average for sexed semen sire fertility. If these bulls best fit your goal of rapid genetic progress, they may not have the CONCEPT PLUS or 511 CONCEPT PLUS designations.

However, if your main focus is to create a pregnancy, the purple 511 CONCEPT PLUS designation will give you confidence you’re boosting your odds at creating pregnancy with sexed semen. The orange CONCEPT PLUS designation will continue to help you recognize which bulls create the most conventional semen pregnancies.

How often does Alta evaluate sire fertility?

We want to help you create more pregnancies. To do that, accurate fertility information is key. To be accurate, the data must be timely. We run a complete evaluate for sire fertility every other month.

We know differences exist in sire fertility, even over shorter periods of time, so to take advantage of the most accurate and current information, we now release new CONCEPT PLUS and 511 CONCEPT PLUS ratings six times per year.

Why should I trust the fertility of Alta 511 CONCEPT PLUS sires?

Alta 511 CONCEPT PLUS sexed sires will give you the confidence to create more heifers and more pregnancies. We provide the utmost care for our bulls, we follow strict lab SOPs, and ensure careful semen distribution procedures. And more importantly, we make firm culling decisions on bulls with sub-par fertility performance.

You can have confidence in the CONCEPT PLUS and 511 CONCEPT PLUS evaluations because:

  • CONCEPT PLUS is COMPLETE
    • It accounts for the effect a technician or breeding code can play on a sire’s fertility within a given herd.
    • Data is collected from US and Canadian herds, and not limited to US herds on official test.
  • CONCEPT PLUS is CURRENT
    • Our team is always collecting data DairyComp in our partner herds.
  • CONCEPT PLUS is CONSISTENT
    • Data is only gathered from progressive, large-herd environments, where management is consistent, contemporary group sizes are large, and repro programs are aggressive.

 

When you want to create more pregnancies, take a precision approach to maximizing your herd’s fertility by using the right tools for the job. Work with your trusted Alta advisor to define your dairy’s customized genetic plan and create pregnancies with a precision approach to fertility management.

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